Marvel United: X-Men
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Can Heroes damage the Villain before two Missions are complete, even with Marrow's Bone Armour or Hulk's area damage?
The designer ruled on this directly on BGG, and the rulebook's Winning & Losing section requires two Missions first.
No. Until the Villain can be damaged, no source can damage it, including area damage and Hero cards such as Marrow's Bone Armour.