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Can Hit and Run deal damage and remove threat when a Patrol minion is engaged with you?

You can still play it. While a Patrol minion is engaged with you, you cannot thwart the main scheme, so that part does nothing (you can still target a side scheme). If the damage defeats the Patrol minion first, the main-scheme threat removal then works, because effects resolve one sentence at a time. The view that the card cannot be played at all was not accepted.

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