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Can I use Guard or other Reaction cards against health loss shown as a heart with a slash?

The designers answered this directly, and it matches the rulebook's text.

  • Final Girl rulebook · Rulebook · Defending Against an Attack with a Reaction Card
  • vanrydergames · Designer · 2021-11-28
  • vanrydergames · Designer · 2022-12-26
  • vanrydergames · Designer · 2023-06-17
  • vanrydergames · Designer · 2025-02-16

No — the heart-with-a-slash icon is unpreventable health loss. Damage shown with the starburst/blast icon or a knife attack can be answered with Reaction cards, even when a Terror card rather than a Killer attack causes it. For enemies, health loss works about the same as damage.

More Final Girl questions · Full rulebook